Mycoplasma Pneumoniae and Diagnostic Insights:
Mycoplasma pneumoniae, a pathogen causing respiratory infections, poses diagnostic challenges due to its limited biosynthetic capacity. Serological testing, particularly MP-IgM antibody determination, serves as a key diagnostic indicator for early infection. With 112 registered test kits, including various methods like colloidal gold and PCR, the Chinese National Medical Products Administration emphasizes diverse diagnostic approaches.
Nitrocellulose Membrane in Immunochromatography:
Critical to lateral immunochromatography test strips, the Nitrocellulose (NC) membrane plays a pivotal role. Comprising sample pad, conjugate pad, reaction membrane (NC membrane), and absorbent pad, these strips facilitate quick and reliable diagnostics.
Cobetter’s Breakthrough with NC Membrane:
Initiating development in 2020, Cobetter has overcome technical challenges to present NC membranes (NC95C and NC140C). These boast exceptional performance, including high porosity, protein binding ability, sensitivity, rapid detection, and hydrophilicity. Variants with diverse pore sizes/climbing speeds are in progress to meet manufacturers’ varied needs.
Key Features of Cobetter NC Membrane:
- High Porosity and Sensitivity: Facilitates excellent protein binding and ensures rapid, sensitive detection.
- Extraordinary Hydrophilicity: Instant wetting for consistent lateral flow, enhancing reliability.
- Low Background: Allows extended exposure time, minimizing interference for precise test results.
- Smooth Surface: Defect-free surface enhances the overall performance of immunochromatography.
- High Consistency: Ensures accurate and reliable test results, a critical aspect for diagnostic efficacy.
Performance Parameters of Cobetter NC Membrane:
NC 95C:
– Total Thickness: 270±20 μm
– Capillary Speed: 90±15s/4cm
– Striping Effect: Straight line without breakpoints or notches
– Protein Adsorption: 30[μg IgG/cm²]
NC 140C:
– Total Thickness: 270±20 μm
– Capillary Speed: 140±20s/4cm
– Striping Effect: Straight line without breakpoints or notches
– Protein Adsorption: 30[μg IgG/cm²]
Applications and Detection Technologies:
Cobetter NC Membrane finds extensive applications in immunochromatography based on lateral flow, including:
– Colloidal Gold Immunochromatography Assay (GICA)
– Latex Immunochromatography Assay
– Fluorescence Immunochromatography Assay
In conclusion, Cobetter NC Membrane emerges as a superior product in the realm of immunochromatography for Mycoplasma pneumoniae detection. Its groundbreaking features and consistent performance parameters position it as a reliable choice for diagnostic manufacturers striving for excellence in diverse lateral flow assays. The pursuit of varied pore sizes further exemplifies Cobetter’s commitment to meeting evolving industry needs, ensuring the continual advancement of immunochromatography applications.
